Cavity Orientation Regulated by Mixture Composition and Clustering of Amphiphilic Cyclodextrins in Phospholipid Monolayers

PINZÓN BARRANTES, JOHN J.

JOURNAL OF PHYSICAL CHEMISTRY B - (Print)

AMER CHEMICAL SOC

Año: 2017 vol. 121 p. 4482 - 4482

1520-6106

rtificial supramolecular-hierarchical structures that emulate nature represent an overcoming alternative for the design of new drug delivery systems. Thermodynamic and topographic properties of films formed by a monoacylated amphiphilic β-cyclodextrin (βCD-C16) with the phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) at the air/water interface were studied. βCD-C16 formed stable mixed films with POPC at several proportions when spread together at the air/water interface. The orientation of βCD-C16 cavity at the interface depends on its mole fraction in the film as reveled by the analysis of partial mean molecular areas as a function of composition. Furthermore, βCD-C16 was able to penetrate POPC preformed films in a broad range of initial surface pressures, including that near the collapse pressure of the phospholipid. These results demonstrated the strong tendency of βCD-C16 to be inserted into this lipid matrix commonly used in lipo